Data quality considerations for evaluating COVID-19 treatments using real world data: learnings from the National COVID Cohort Collaborative (N3C).

ABSTRACT:

Background

Multi-institution electronic health records (EHR) are a rich source of real world data (RWD) for generating real world evidence (RWE) regarding the utilization, benefits and harms of medical interventions. They provide access to clinical data from large pooled patient populations in addition to laboratory measurements unavailable in insurance claims-based data. However, secondary use of these data for research requires specialized knowledge and careful evaluation of data quality and completeness. We discuss data quality assessments undertaken during the conduct of prep-to-research, focusing on the investigation of treatment safety and effectiveness.

Methods

Using the National COVID Cohort Collaborative (N3C) enclave, we defined a patient population using criteria

SUBMITTER: Sidky H 

PROVIDER: S-EPMC9936475 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature