P7C3-A20 Attenuates Microglial Inflammation and Brain Injury after ICH through Activating the NAD⁺/Sirt3 Pathway.

ABSTRACT: Intracerebral hemorrhage (ICH) is lethal but lacks effective therapies. Nicotinamide adenine dinucleotide (NAD⁺) is a central metabolite indispensable for a broader range of fundamental intracellular biological functions. Reduction of NAD⁺ usually occurs after acute brain insults, and supplementation of NAD⁺ has been proven neuroprotective. P7C3-A20 is a novel compound featuring its ability to facilitate the flux of NAD⁺. In this study, we sought to determine the potential therapeutic value of P7C3-A20 in ICH. In collagenase-induced ICH mouse models, we found that P7C3-A20 treatment could diminish lesion volume, reduce blood-brain barrier (BBB) damage, mitigate brain edema, attenuate neural apoptosis, and improve neurological outcomes after ICH.

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9936507 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature