Identification of Gene Signature-Related Oxidative Stress for Predicting Prognosis of Colorectal Cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is the third most common cancer. Nearly a decade of studies had shown that cancer regimens tailored to molecular and pathological features lead to improved overall survival. Oxidative stress (OS) refers to a state in which oxidation and antioxidant effects are unbalanced in the body. However, the molecular mechanism of OS-related CRC remains unclear.

Methods

Univariate Cox regression analysis gained OS signature genes related to CRC prognosis, and then, different CRC molecular subtypes were obtained by consensus clustering analysis. Differential expression analysis and least absolute shrinkage and selection operator (LASSO) algorithm were used to obtain prognostic-related signature genes. Significantly, risk score was calculated by RiskScor

SUBMITTER: Wang X 

PROVIDER: S-EPMC9936508 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature