STING as an emerging therapeutic target for drug discovery: Perspectives from the global patent landscape.

ABSTRACT:

Background

The STimulator of INterferon Genes (STING) plays an essential role in the innate immune system by inducing the expression of type I interferons (IFNs) and inflammatory cytokines upon sensing cytosolic DNA. Although modulating STING has shown promise as a potential treatment for cancers and inflammatory and autoimmune diseases in substantial pre-clinical studies, current preliminary clinical results of STING agonists have demonstrated limited anti-tumor efficacy. Currently, there is ongoing R&D targeting STING and focusing on the delivery of next-generation therapeutics. Whereas no comprehensive analysis on the STING patent landscape has been conducted to fill the gap between basic research progress and drug development and commercialization.

Aim of review

This stu

SUBMITTER: Kong X 

PROVIDER: S-EPMC9936525 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature