Fecal microbiota transplantation attenuates Escherichia coli infected outgrowth by modulating the intestinal microbiome.

ABSTRACT:

Background

Given the crucial role of gut microbiota in animal and human health, studies on modulating the intestinal microbiome for therapeutic purposes have grasped a significant attention, of which the role of fecal microbiota transplantation (FMT) has been emphasized.

Methods

In the current study, we evaluated the effect of FMT on gut functions in Escherichia coli (E. coli) infection by using mice model. Moreover, we also investigated the subsequently dependent variables of infection, i.e., body weight, mortality, intestinal histopathology, and the expression changes in tight junction proteins (TJPs).

Results

The FMT effectively decreased weight loss and mortality to a certain extent with the restoration of intestinal villi that resulted in high histological scores

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9936653 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature