Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles.

ABSTRACT:

Background

Reduced heart rate (HR) during vagus nerve stimulation (VNS) is associated with therapy for heart failure, but stimulation frequency and amplitude are limited by patient tolerance. An understanding of physiological responses to parameter adjustments would allow differential control of therapeutic and side effects. To investigate selective modulation of the physiological responses to VNS, we quantified the effects and interactions of parameter selection on two physiological outcomes: one related to therapy (reduced HR) and one related to side effects (laryngeal muscle EMG).

Methods

We applied a broad range of stimulation parameters (mean pulse rates (MPR), intra-burst frequencies, and amplitudes) to the vagus nerve of anesthetized mice. We leveraged the in vivo rec

SUBMITTER: Huffman WJ 

PROVIDER: S-EPMC9936668 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature