Identification of HOXB9 to predict prognosis of endometrial cancer based on comprehensive bioinformatics analysis.

ABSTRACT:

Background

The HOXB9 gene, which plays a key role in embryonic development, is also involved in the regulation of various human cancers. However, the potential relationship between HOXB9 and endometrial cancer (EC) has not yet been comprehensively analyzed and fully understood.

Methods

We used multiple bioinformatics tools to explore the role of HOXB9 in EC.

Results

The expression of HOXB9 was significantly upregulated in pan-cancer, including EC (P < 0.05). Quantitative real time polymerase chain reaction (qRT-PCR) experiment confirmed the high expression of HOXB9 in EC from clinical samples (P < 0.001). Double validated by Enrichr and Metascape, HOXB9 showed a strong correlation with HOX family, suggesting that HOX family may also involve in the development of EC (P

SUBMITTER: Xu Y 

PROVIDER: S-EPMC9936693 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature