Screening and identification of miR-181a-5p in oral squamous cell carcinoma and functional verification in vivo and in vitro.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, the role of miRNAs in OSCC development and progression is not well understood.

Methods

We sought to establish a dynamic Chinese hamster OSCC animal model, construct miRNA differential expression profiles of its occurrence and development, predict its targets, and perform functional analysis and validation in vitro.

Results

Using expression and functional analyses, the key candidate miRNA (miR-181a-5p) was selected for further functional research, and the expression of miR-181a-5p in OSCC tissues and cell lines was detected. Subsequently, transfection technology and a nude mouse t

SUBMITTER: Xu G 

PROVIDER: S-EPMC9936757 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature