Autoimmunity in Infection-Related Glomerulonephritis.

ABSTRACT:

Introduction

Autoimmune (AI) reactivity in the setting of infection-related GN (IRGN) is often viewed as an epiphenomenon and is not well described.

Methods

We report a cohort of 17 patients with IRGN during a 7-year period that highlights cases with AI reactivity and describes the clinical and pathologic characteristics of IRGN cases associated with AI reactivity.

Results

Of the IRGN cases, 76% had clinical evidence of an autoimmune disease (AD) and/or positive AI serologies. Within the IRGN group with AI reactivity, 12 had positive AI serologies (92%) and 10 had AD (77%). 30% had a prior diagnosis of AD, while the remaining 70% did not have a history of AD and were either diagnosed or suspected of having an AD at the time of biopsy. The most common autoantibody dete

SUBMITTER: Choung HYG 

PROVIDER: S-EPMC9936758 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature