NELL1-Positive HIV-Associated Lupus-Like Membranous Nephropathy with Spontaneous Remission.

ABSTRACT:

Introduction

Kidney biopsy findings in patients with human immunodeficiency virus (HIV) are diverse, and optimal therapy for the various immune complex diseases in the setting of HIV is unknown.

Case presentation

A man with well-controlled HIV developed nephrotic range proteinuria, and kidney biopsy revealed lupus-like glomerulonephritis with a predominantly membranous pattern of injury. He opted for conservative therapy and experienced spontaneous and sustained remission. Subsequent testing revealed neural epidermal growth factor-like 1 (NELL1)-positive glomerular immune deposits. NELL1-positive glomerular immune deposits were identified in a total of 2 of 5 tested HIV-associated membranous nephropathy (MN), which were morphologically dissimilar and one of which weakly co-e

SUBMITTER: Dinesh KP 

PROVIDER: S-EPMC9936763 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature