Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.

ABSTRACT:

Background

Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations. It is the most common cause of secondary glaucoma, resulting in widespread global blindness. The largest global meta-analysis of XFS in 123,457 multi-ethnic individuals from 24 countries identified seven loci with the strongest association signal in chr15q22-25 region near LOXL1. Expression analysis have so far correlated coding and a few non-coding variants in the region with LOXL1 expression levels, but functional effects of these variants is unclear. We hypothesize that analysis of the contribution of the genetically determined component of gene expression to XFS

SUBMITTER: Hirbo JB 

PROVIDER: S-EPMC9936777 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature