Regional distribution and maturation of tau pathology among phenotypic variants of Alzheimer's disease.

ABSTRACT: Alzheimer's disease neuropathologic change (ADNC) is clinically heterogenous and can present with a classic multidomain amnestic syndrome or focal non-amnestic syndromes. Here, we investigated the distribution and burden of phosphorylated and C-terminally cleaved tau pathologies across hippocampal subfields and cortical regions among phenotypic variants of Alzheimer's disease (AD). In this study, autopsy-confirmed patients with ADNC, were classified into amnestic (aAD, N = 40) and non-amnestic (naAD, N = 39) groups based on clinical criteria. We performed digital assessment of tissue sections immunostained for phosphorylated-tau (AT8 detects pretangles and mature tangles), D⁴²¹-truncated tau (TauC3, a marker for mature tangles and ghost tangles), and E³⁹¹-truncated ta

SUBMITTER: Arezoumandan S 

PROVIDER: S-EPMC9936795 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature