Enhancing ¹⁹F Benchtop NMR Spectroscopy by Combining para-Hydrogen Hyperpolarization and Multiplet Refocusing.

ABSTRACT: Benchtop NMR spectrometers provide a promising alternative to high-field NMR for applications that are limited by instrument size and/or cost. ¹⁹F benchtop NMR is attractive due to the larger chemical shift range of ¹⁹F relative to ¹H and the lack of background signal in most applications. However, practical applications of benchtop ¹⁹F NMR are limited by its low sensitivity due to the relatively weak field strengths of benchtop NMR spectrometers. Here we present a sensitivity-enhancement strategy that combines SABRE (Signal Amplification By Reversible Exchange) hyperpolarization with the multiplet refocusing method SHARPER (Sensitive, Homogeneous, And Resolved PEaks in Real time). When applied to a range of fluoropyridines, SABRE-SHARPER achieve

SUBMITTER: Silva Terra AI 

PROVIDER: S-EPMC9936801 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature