Derivatization of graphene oxide nanosheets with tunable nitric oxide release for antibacterial biomaterials.

ABSTRACT: Graphene oxide (GO) nanosheets are a promising class of carbon-based materials suitable for application in the construction of medical devices. These materials have inherent antimicrobial properties based on sheet size, but these effects must be carefully traded off to maintain biocompatibility. Chemical modification of functional groups to the lattice structure of GO nanosheets enables unique opportunities to introduce new surface properties to bolster biological effects. Herein, we have developed nitric oxide (NO)-releasing GO nanosheets via immobilization of S-nitrosothiol (RSNO) moieties to GO nanosheets (GO-[NH]_x -SNO). These novel RSNO-based GO nanosheets were characterized for chemical functionality via Fourier transform infrared spectroscopy, x-ray photoelectron spectros

SUBMITTER: Garren M 

PROVIDER: S-EPMC9936865 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature