Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy.

ABSTRACT:

Background and aims

In biliary atresia, serum bilirubin is commonly used to predict outcomes after Kasai portoenterostomy (KP). Infants with persistently high levels invariably need liver transplant, but those achieving normalized levels have a less certain disease course. We hypothesized that serum bile acid levels could help predict outcomes in the latter group.

Approach and results

Participants with biliary atresia from the Childhood Liver Disease Research Network were included if they had normalized bilirubin levels 6 months after KP and stored serum samples from the 6-month post-KP clinic visit ( n  = 137). Bile acids were measured from the stored serum samples and used to divide participants into ≤40 μmol/L ( n  = 43) or >40 μmol/L ( n  = 94) groups. At 2 years of age,

SUBMITTER: Harpavat S 

PROVIDER: S-EPMC9936974 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature