Transcriptional Regulation of Math1 by Aryl Hydrocarbon Receptor: Effect on Math1⁺ Progenitor Cells in Mouse Small Intestine.

ABSTRACT: The physiological roles of aryl hydrocarbon receptor (AhR) in the small intestine have been revealed as immunomodulatory and barrier functions. However, its contributions to cell fate regulation are incompletely understood. The Notch-activated signaling cascade is a central component of intestinal cell fate determinations. The lateral inhibitory mechanism governed by Notch directs cell fates toward distinct cell lineages (i.e., absorptive and secretory cell lineages) through its downstream effector, mouse atonal homolog 1 (MATH1). An investigation employing cell lines and intestinal crypt cells revealed that AhR regulates Math1 expression in a xenobiotic response element (XRE)-dependent manner. The AhR-Math1 axis was further addressed using intestinal organoids, where AhR-

SUBMITTER: Yagishita Y 

PROVIDER: S-EPMC9937019 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature