RTMS investigation of resistant Obsessive-Compulsive Related Disorders: Efficacy of targeting the reward system.

ABSTRACT:

Introduction

Repetitive Transcranial Magnetic Stimulation (rTMS) is not only a therapeutic option but also an investigational tool to explore circuits and subjective dimensions in pathological conditions. Obsessive-Compulsive Related Disorders (OCRDs) shared similarities with Substance Use Disorder (SUD), suggesting the involvement of the reward system. This study aimed to verify the efficacy of targeting the reward system with rTMS in OCRDs.

Methods

Patients with trichotillomania, hoarding disorder and skin picking disorder were treated with rTMS over the left DorsoLateral PreFrontal Cortex (DLPFC) at 15 Hz, targeting the reward system via the connection with the nucleus accumbens and the ventral tegmental area. All patients were administered with psychometric scales assess

SUBMITTER: Di Ponzio M 

PROVIDER: S-EPMC9937025 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature