Higher stress response and altered quality of life in schizophrenia patients with low membrane levels of docosahexaenoic acid.

ABSTRACT: Schizophrenia is a severe, chronic, and heterogeneous mental disorder that affects approximately 1% of the world population. Ongoing research aims at clustering schizophrenia heterogeneity into various "biotypes" to identify subgroups of individuals displaying homogeneous symptoms, etiopathogenesis, prognosis, and treatment response. The present study is in line with this approach and focuses on a biotype partly characterized by a specific membrane lipid composition. We have examined clinical and biological data of patients with stabilized schizophrenia, including the fatty acid content of their erythrocyte membranes, in particular the omega-3 docosahexaenoic acid (DHA). Two groups of patients of similar size were identified: the DHA- group (N = 19) with a lower proportion of membra

SUBMITTER: Adrien V 

PROVIDER: S-EPMC9937080 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature