Human-gained heart enhancers are associated with species-specific cardiac attributes.

ABSTRACT: The heart, a vital organ which is first to develop, has adapted its size, structure and function in order to accommodate the circulatory demands for a broad range of animals. Although heart development is controlled by a relatively conserved network of transcriptional/chromatin regulators, how the human heart has evolved species-specific features to maintain adequate cardiac output and function remains to be defined. Here, we show through comparative epigenomic analysis the identification of enhancers and promoters that have gained activity in humans during cardiogenesis. These cis-regulatory elements (CREs) are associated with genes involved in heart development and function, and may account for species-specific differences between human and mouse hearts. Supporting these findings, geneti

SUBMITTER: Destici E 

PROVIDER: S-EPMC9937543 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature