Poly(l-lactic acid) Scaffold Releasing an α₄β₁ Integrin Agonist Promotes Nonfibrotic Skin Wound Healing in Diabetic Mice.

ABSTRACT: Skin wound healing is a highly complex process that continues to represent a major medical problem, due to chronic nonhealing wounds in several classes of patients and to possible fibrotic complications, which compromise the function of the dermis. Integrins are transmembrane receptors that play key roles in this process and that offer a recognized druggable target. Our group recently synthesized GM18, a specific agonist for α4β1, an integrin that plays a role in skin immunity and in the migration of neutrophils, also regulating the differentiated state of fibroblasts. GM18 can be combined with poly(l-lactic acid) (PLLA) nanofibers to provide a controlled release of this agonist, resulting in a medication particularly suitable for skin wounds. In this study, we first optimized a GM18-PLLA

SUBMITTER: Baldassarro VA 

PROVIDER: S-EPMC9937562 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature