Ontology highlight
ABSTRACT:
SUBMITTER: Ghelani T
PROVIDER: S-EPMC9937578 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Ghelani Tina T Escher Marc M Thomas Ulrich U Esch Klara K Lützkendorf Janine J Depner Harald H Maglione Marta M Parutto Pierre P Gratz Scott S Matkovic-Rachid Tanja T Ryglewski Stefanie S Walter Alexander M AM Holcman David D O'Connor Giles Kate K Heine Martin M Sigrist Stephan J SJ
Science advances 20230217 7
At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca<sup>2+</sup> channels (VGCCs). While AZs can potentiate SV release in the minutes range, we lack an understanding of how AZ scaffold components and VGCCs engage into potentiation. We here establish dynamic, intravital single-molecule imaging of endogenously tagged proteins at <i>Drosophila</i> AZs undergoing presy ...[more]