Examination of runs of homozygosity in relation to height in an endogamous Namibian population.

ABSTRACT:

Objectives

Height is a complex, highly heritable polygenic trait subject to both genetic composition and environmental influences. Recent studies suggest that a large proportion of height heritability is determined by the cumulative effect of many low allele frequency variants across the genome. Previous research has also identified an inverse relationship between height and runs of homozygosity (ROH); however, this has yet to be examined within African populations. We aim to identify this association within the Himba, an endogamous Namibian population who are recently bottlenecked, resulting in elevated haplotype sharing and increased homozygosity.

Materials and methods

Here, we calculate the fraction of the genome composed of long runs of homozygosity (F_ROH) in

SUBMITTER: Swinford N 

PROVIDER: S-EPMC9937629 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature