Attention-deficit/hyperactivity disorder and white matter microstructure: the importance of dimensional analyses and sex differences.

ABSTRACT:

Background

Attention-deficit/hyperactive disorder (ADHD) has substantial heterogeneity in clinical presentation. A potentially important clue may be variation in brain microstructure. Using fractional anisotropy (FA), previous studies have produced equivocal results in relation to ADHD. This may be due to insufficient consideration of possible sex differences and ADHD's multi-componential nature.

Methods

Using whole-brain analyses, we investigated the association between FA and both ADHD diagnosis and ADHD symptom domains in a well-characterized, ADHD (n = 234; 32% female youth) and non-ADHD (n = 177; 52% female youth), case-control cohort (ages 7-12). Sex-specific effects were tested.

Results

No ADHD group differences were found using categorical assessment of ADHD w

SUBMITTER: Jones SA 

PROVIDER: S-EPMC9937645 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature