Ontology highlight
ABSTRACT:
SUBMITTER: Yamada D
PROVIDER: S-EPMC9937650 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Yamada Daichi D Bushey Daniel D Li Feng F Hibbard Karen L KL Sammons Megan M Funke Jan J Litwin-Kumar Ashok A Hige Toshihide T Aso Yoshinori Y
eLife 20230124
Dopaminergic neurons with distinct projection patterns and physiological properties compose memory subsystems in a brain. However, it is poorly understood whether or how they interact during complex learning. Here, we identify a feedforward circuit formed between dopamine subsystems and show that it is essential for second-order conditioning, an ethologically important form of higher-order associative learning. The <i>Drosophila</i> mushroom body comprises a series of dopaminergic compartments, ...[more]