Integrative network pharmacology and in silico analyses identify the anti-omicron SARS-CoV-2 potential of eugenol.

ABSTRACT: Eugenol as a natural product is the source of isoniazid, and purified eugenol is extensively used in the cosmetics industry and the productive processes of edible spices. Accumulating evidence suggested that eugenol exerted potent anti-microorganism and anti-inflammation effects. Application of eugenol effectively reduced the risk of atherosclerosis, arterial embolism, and Type 2 diabetes. A previous study confirmed that treatment with eugenol attenuated lung inflammation and improved heart functions in SARS-CoV-2 spike S1-intoxicated mice. In addition to the study, based on a series of public datasets, computational analyses were conducted to characterize the acting targets of eugenol and the functional roles of these targets in COVID-19. The binding capacities of eugenol to conservative

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9937729 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature