Specific immunoglobulin G4 correlates with Th2 cytokine reduction in patients with allergic asthma treated by Dermatophagoides pteronyssinus subcutaneous immunotherapy.

ABSTRACT:

Background

The modulations of lymphocyte subsets and cytokine production due to subcutaneous allergen immunotherapy (SCIT) are not fully clarified.

Objective

We investigated the changes in T-lymphocyte subsets and serum Dermatophagoides pteronyssinus-specific immunoglobulin G4 (Der-p sIgG4), as well as cytokine production during Der-p SCIT, in patients with allergic asthma.

Methods

This study involved 20 patients with allergic asthma who were receiving 156-week Der-p SCIT and 20 patients without SCIT (non-SCIT). We measured symptom and medication scores (SMS), serum Der-p sIgG4 levels, CD4⁺CD25⁺Foxp3⁺ T regulatory (Treg), CD4⁺IL-4^-IFN-γ⁺ T-helper (Th) 1, and CD4⁺IL-4⁺IFN-γ

SUBMITTER: Su Q 

PROVIDER: S-EPMC9937843 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature