Longitudinal study of Alzheimer's disease biomarkers, allostatic load, and cognition among memory clinic patients.

ABSTRACT:

Background

Allostatic load (AL) is defined as the cumulative dysregulation of neuroendocrine, immunological, metabolic, and cardiovascular systems that increases the susceptibility to stress-related health problems. Several dementia and Alzheimer's disease (AD) risk factors have been identified, yet little is known about the role of AL and its associations with AD biomarkers (e.g., beta-amyloid (Aβ) or tau) and cognitive function among memory clinic patients. Hence, this study aims to assess the association between AL and AD biomarkers, cognitive performance, and cognitive decline after 3-years of follow-up.

Methods

Data from 188 memory clinic patients were derived from the Cortisol and Stress in AD (Co-STAR) study in Sweden. Participants underwent baseline assessments inclu

SUBMITTER: Adedeji DO 

PROVIDER: S-EPMC9937889 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature