Development and internal validation of a predictive score for the diagnosis of central adrenal insufficiency when morning cortisol is in the grey zone.

ABSTRACT:

Background

When evaluating a patient for central adrenal insufficiency (CAI), there is a wide range of morning cortisol values for which no definite conclusion on hypothalamus-pituitary-adrenal (HPA) axis function can be drawn; in these cases, a stimulation test is required. Aim of this study was to develop an integrated model for CAI prediction when morning cortisol is in the grey zone, here defined as 40.0-160.0 μg/L.

Methods

Overall, 119 patients with history of sellar tumour which underwent insulin tolerance test (ITT) for the evaluation of HPA axis were enrolled. Supervised regression techniques were used for model development.

Results

An integrated predictive model was developed and internally validated, and showed a significantly better diagnostic performance t

SUBMITTER: Bioletto F 

PROVIDER: S-EPMC9938019 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature