A prognostic score based on B cell and plasma cell densities compared to T cell densities in colorectal cancer.

ABSTRACT:

Purpose

The purpose of this study was to compare a B cell/plasma cell-based scoring system to T cell score and evaluate their prognostic value in colorectal cancer.

Methods

We used immunohistochemistry to analyze the expression of CD20, CD138, CD3, and CD8 in 221 colorectal cancer patients. CD20+ B cell and CD138+ plasma cell densities in the tumor center and invasive margin were calculated and converted into a B cell/plasma cell score. T cell score was defined similarly, using CD3+ and CD8+ T cell densities. Their associations with tumor and patient characteristics and survival were analyzed.

Results

Kaplan-Meier analysis showed a high B cell/plasma cell score was associated with a tendency towards longer survival (p = 0.089), but no statistically significant associa

SUBMITTER: Karjalainen H 

PROVIDER: S-EPMC9938036 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature