Fecal microbiota composition is related to brown adipose tissue ¹⁸F-fluorodeoxyglucose uptake in young adults.

ABSTRACT:

Objective

Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and its related cardiometabolic diseases; however, whether the gut microbiota might be an efficient stimulus to activate BAT metabolism remains to be ascertained. We aimed to investigate the association of fecal microbiota composition with BAT volume and activity and mean radiodensity in young adults.

Methods

82 young adults (58 women, 21.8 ± 2.2 years old) participated in this cross-sectional study. DNA was extracted from fecal samples and 16S rRNA sequencing was performed to analyse the fecal microbiota composition. BAT was determined via a static ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography-computed tomography sc

SUBMITTER: Ortiz-Alvarez L 

PROVIDER: S-EPMC9938059 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature