Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts.

ABSTRACT: Substance use disorders (SUDs) incur serious social and personal costs. The risk for SUDs is complex, with risk factors ranging from social conditions to individual genetic variation. We examined whether models that include a clinical/environmental risk index (CERI) and polygenic scores (PGS) are able to identify individuals at increased risk of SUD in young adulthood across four longitudinal cohorts for a combined sample of N = 15,134. Our analyses included participants of European (N_EUR = 12,659) and African (N_AFR = 2475) ancestries. SUD outcomes included: (1) alcohol dependence, (2) nicotine dependence; (3) drug dependence, and (4) any substance dependence. In the models containing the PGS and CERI, the CERI was associated with all three outcomes (ORs = 01.37-1.67)

SUBMITTER: Barr PB 

PROVIDER: S-EPMC9938102 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature