Microarray transcriptome datasets of maternal-zygotic DNA methyltransferase 3aa ^-/- zebrafish during early developmental stages.

ABSTRACT: DNA methylation is an epigenetic regulator mediated by DNA methyltransferases (Dnmts). The methylation is involved in control of gene expression in vertebrates. It has been reported that there are mainly two types of de novo Dnmts, Dnmt3a and Dnmt3b, in mammals. These two Dnmts function in DNA methylation in the distinct or overlapping genomic regions. The zebrafish homologs of mammalian Dnmt3a are Dnmt3aa and Dnmt3ab. We generated a maternal-zygotic dnmt3aa deficient mutant (MZdnmt3aa) to identify the specific target regions for DNA methylation in the zebrafish genome and their function in the developmental process. Microarray analysis revealed alterations in gene expression by knock-out of dnmt3aa in early zebrafish development. Microarray datasets were produc

SUBMITTER: Shirai M 

PROVIDER: S-EPMC9938149 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature