The GABA_A receptor modulator zolpidem augments hippocampal-prefrontal coupling during non-REM sleep.

ABSTRACT: Benzodiazepines and 'Z-drugs' (including zolpidem and zopiclone) are GABA_A receptor (GABA_AR) positive modulators commonly prescribed as hypnotics to treat insomnia and/or anxiety. However, alongside sedation, augmenting GABA_AR function may also alter coordinated neuronal activity during sleep, thereby influencing sleep-dependent processes including memory consolidation. We used simultaneous recordings of neural population activity from the medial prelimbic cortex (PrL) and CA1 of the dorsal hippocampus (dCA1) of naturally sleeping rats to detail the effects of zolpidem on network activity during the cardinal oscillations of non-REM sleep. For comparison, we also characterized the effects of diazepam and 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP/g

SUBMITTER: Kersante F 

PROVIDER: S-EPMC9938179 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature