A mathematical model of fibrinogen-mediated erythrocyte-erythrocyte adhesion.

ABSTRACT: Erythrocytes are deformable cells that undergo progressive biophysical and biochemical changes affecting the normal blood flow. Fibrinogen, one of the most abundant plasma proteins, is a primary determinant for changes in haemorheological properties, and a major independent risk factor for cardiovascular diseases. In this study, the adhesion between human erythrocytes is measured by atomic force microscopy (AFM) and its effect observed by micropipette aspiration technique, in the absence and presence of fibrinogen. These experimental data are then used in the development of a mathematical model to examine the biomedical relevant interaction between two erythrocytes. Our designed mathematical model is able to explore the erythrocyte-erythrocyte adhesion forces and changes in erythrocyte mor

SUBMITTER: Lopes CS 

PROVIDER: S-EPMC9938206 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature