Electrophysiological signatures of reward learning in the rodent touchscreen-based Probabilistic Reward Task.

ABSTRACT: Blunted reward learning and reward-related activation within the corticostriatal-midbrain circuitry have been implicated in the pathophysiology of anhedonia and depression. Unfortunately, the search for more efficacious interventions for anhedonic behaviors has been hampered by the use of vastly different preclinical and clinical assays. In a first step in addressing this gap, in the current study, we used event-related potentials and spectral analyses in conjunction with a touchscreen version of the rodent Probabilistic Reward Task (PRT) to identify the electrophysiological signatures of reward learning in rats. We trained 11 rats (5 females and 6 males) on the rodent touchscreen-based PRT and subsequently implanted them with deep electrodes in the anterior cingulate cortex (ACC) and nucl

SUBMITTER: Iturra-Mena AM 

PROVIDER: S-EPMC9938210 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature