Body shape phenotypes of multiple anthropometric traits and cancer risk: a multi-national cohort study.

ABSTRACT:

Background

Classical anthropometric traits may fail to fully represent the relationship of weight, adiposity, and height with cancer risk. We investigated the associations of body shape phenotypes with the risk of overall and site-specific cancers.

Methods

We derived four distinct body shape phenotypes from principal component (PC) analysis on height, weight, body mass index (BMI), waist (WC) and hip circumferences (HC), and waist-to-hip ratio (WHR). The study included 340,152 men and women from 9 European countries, aged mostly 35-65 years at recruitment (1990-2000) in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards regression was used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals

SUBMITTER: Sedlmeier AM 

PROVIDER: S-EPMC9938222 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature