Individualized functional connectome identified generalizable biomarkers for psychiatric symptoms in transdiagnostic patients.

ABSTRACT: Substantial clinical heterogeneity and comorbidity inherent amongst mental disorders limit the identification of neuroimaging biomarkers that can reliably track clinical symptoms. Strategies that enable generation of meaningful and replicable neurobiological markers at the individual level will push the field of neuropsychiatry forward in developing efficacious personalized treatment. The current study included 142 adult patients with a primary diagnosis of schizophrenia (SCZ), bipolar (BP), or attention deficit/hyperactivity disorder (ADHD), and 67 patient ratings across four behavioral measures. Using functional connectivity derived from a personalized fMRI approach, we identified several candidate imaging markers related to dimensional phenotypes across disorders, assessed the internal

SUBMITTER: Li M 

PROVIDER: S-EPMC9938230 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature