Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value.

ABSTRACT:

Background

The endometrial cancer mismatch repair (MMR) deficient subgroup is defined by loss of MSH6, MSH2, PMS2 or MLH1. We compare MMR status in paired preoperative and operative samples and investigate the prognostic impact of differential MMR protein expression levels.

Methods

Tumour lesions from 1058 endometrial cancer patients were immunohistochemically stained for MSH6, MSH2, PMS2 and MLH1. MMR protein expression was evaluated as loss or intact to determine MMR status, or by staining index to evaluate the prognostic potential of differential expression. Gene expression data from a local (n = 235) and the TCGA (n = 524) endometrial cancer cohorts was used for validation.

Results

We identified a substantial agreement in MMR status between paired curettage and hy

SUBMITTER: Berg HF 

PROVIDER: S-EPMC9938259 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature