Cholinergic system adaptations are associated with cognitive function in people recently abstinent from smoking: a (-)-[¹⁸F]flubatine PET study.

ABSTRACT: The cholinergic system is a critical mediator of cognition in animals. People who smoke cigarettes exhibit cognitive deficits, especially during quit attempts. Few studies jointly examine the cholinergic system and cognition in people while trying to quit smoking. We used positron emission tomography (PET) brain imaging with the β₂-subunit containing nicotinic acetylcholine receptor (β₂*-nAChR) partial agonist radioligand (-)-[¹⁸F]flubatine and the acetylcholinesterase inhibitor physostigmine to jointly examine the cholinergic system, smoking status, and cognition. (-)-[¹⁸F]Flubatine scans and cognitive data were acquired from twenty people who recently stopped smoking cigarettes (aged 38 ± 11 years; 6 female, 14 male; abstinent 7 ± 1 days) and 2

SUBMITTER: Calakos KC 

PROVIDER: S-EPMC9938267 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature