Efficacy and safety of radiation therapy in advanced adrenocortical carcinoma.

ABSTRACT:

Background

International guidelines emphasise the role of radiotherapy (RT) for the management of advanced adrenocortical carcinoma (ACC). However, the evidence for this recommendation is very low.

Methods

We retrospectively analysed all patients who received RT for advanced ACC in five European centres since 2000.

Primary endpoint

time to progression of the treated lesion (tTTP). Secondary endpoints: best objective response, progression-free survival (PFS), overall survival (OS), adverse events, and the establishment of predictive factors by Cox analyses.

Results

In total, 132 tumoural lesions of 80 patients were treated with conventional RT (cRT) of 50-60 Gy (n = 20) or 20-49 Gy (n = 69), stereotactic body RT of 35-50 Gy (SBRT) (n = 36), or brachytherapy of 1

SUBMITTER: Kimpel O 

PROVIDER: S-EPMC9938283 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature