Loss of skeletal muscle estrogen-related receptors leads to severe exercise intolerance.

ABSTRACT:

Objective

Skeletal muscle oxidative capacity is central to physical activity, exercise capacity and whole-body metabolism. The three estrogen-related receptors (ERRs) are regulators of oxidative metabolism in many cell types, yet their roles in skeletal muscle remain unclear. The main aim of this study was to compare the relative contributions of ERRs to oxidative capacity in glycolytic and oxidative muscle, and to determine defects associated with loss of skeletal muscle ERR function.

Methods

We assessed ERR expression, generated mice lacking one or two ERRs specifically in skeletal muscle and compared the effects of ERR loss on the transcriptomes of EDL (predominantly glycolytic) and soleus (oxidative) muscles. We also determined the consequences of the loss of ERRs for ex

SUBMITTER: Wattez JS 

PROVIDER: S-EPMC9938320 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature