Intrinsic cardiorespiratory fitness modulates clinical and molecular response to caloric restriction.

ABSTRACT:

Objective

Caloric restriction (CR) is one extrinsic intervention that can improve metabolic health, and it shares many phenotypical parallels with intrinsic high cardiorespiratory fitness (CRF), including reduced adiposity, increased cardiometabolic health, and increased longevity. CRF is a highly heritable trait in humans and has been established in a genetic rat model selectively bred for high (HCR) and low (LCR) CRF, in which the HCR live longer and have reduced body weight compared to LCR. This study addresses whether the inherited high CRF phenotype occurs through similar mechanisms by which CR promotes health and longevity.

Methods

We compared HCR and LCR male rats fed ad libitum (AL) or calorically restricted (CR) for multiple physiological, metabolic, and molecular t

SUBMITTER: Fleischman JY 

PROVIDER: S-EPMC9938335 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature