Association of Hypertensive Disorders of Pregnancy With Future Cardiovascular Disease.

ABSTRACT:

Importance

Hypertensive disorders in pregnancy (HDPs) are major causes of maternal and fetal morbidity and are observationally associated with future maternal risk of cardiovascular disease. However, observational results may be subject to residual confounding and bias.

Objective

To investigate the association of HDPs with multiple cardiovascular diseases.

Design, setting, and participants

A genome-wide genetic association study using mendelian randomization (MR) was performed from February 16 to March 4, 2022. Primary analysis was conducted using inverse-variance-weighted MR. Mediation analyses were performed using a multivariable MR framework. All studies included patients predominantly of European ancestry. Female-specific summary-level data from FinnGen (sixth rel

SUBMITTER: Rayes B 

PROVIDER: S-EPMC9938428 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature