Monoclonal Antibody for the Prevention of Respiratory Syncytial Virus in Infants and Children: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Importance

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infection in children younger than 5 years; effective prevention strategies are urgently needed.

Objective

To compare the efficacy and safety of monoclonal antibodies for the prevention of RSV infection in infants and children.

Data sources

In this systematic review and network meta-analysis, PubMed, Embase, CENTRAL, and ClinicalTrials.gov were searched from database inception to March 2022.

Study selection

Randomized clinical trials that enrolled infants at high risk of RSV infection to receive a monoclonal antibody or placebo were included. Keywords and extensive vocabulary related to monoclonal antibodies, RSV, and randomized clinical trials were searched.

Data ex

SUBMITTER: Sun M 

PROVIDER: S-EPMC9938429 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature