WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.

ABSTRACT:

Background

Large tumor suppressor kinase 1 (LATS1), one of the predominant components of the Hippo pathway, has been characterized as a key player controlling the proliferation and invasion of cancer cells, including gastric cancer (GC) cells. However, the mechanism by which the functional stability of LATS1 is modulated has yet to be elucidated.

Methods

Online prediction tools, immunohistochemistry and western blotting assays were used to explore the expression of WW domain-containing E3 ubiquitin ligase 2 (WWP2) in GC cells and tissues. Gain- and loss-of-function assays, as well as rescue experiments were performed to determine the role of the WWP2-LATS1 axis in cell proliferation and invasion. Additionally, the mechanisms involving WWP2 and LATS1 were assessed by coimmuno

SUBMITTER: Zou J 

PROVIDER: S-EPMC9938551 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature