Plasma levels and tissue expression of liver-type fatty acid-binding protein in patients with breast cancer.

ABSTRACT:

Background

Liver-type fatty acid-binding protein (L-FABP) is widely expressed in hepatocytes and plays a role in lipid metabolism. It has been demonstrated to be overexpressed in different types of cancer; however, few studies have investigated the association between L-FABP and breast cancer. The aim of this study was to assess the association between plasma concentrations of L-FABP in breast cancer patients and the expression of L-FABP in breast cancer tissue.

Method

A total of 196 patients with breast cancer and 57 age-matched control subjects were studied. Plasma L-FABP concentrations were measured using ELISA in both groups. The expression of L-FABP in breast cancer tissue was examined using immunohistochemistry.

Result

The patients had higher plasma L-FABP level

SUBMITTER: Chang CC 

PROVIDER: S-EPMC9938596 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature