Qihuang Granule protects the retinal pigment epithelium from oxidative stress via regulation of the alternative complement pathway.

ABSTRACT:

Background

Age-related macular degeneration (AMD) is a leading cause of vision loss in elderly people, and dry AMD is the most common type of AMD. Oxidative stress and alternative complement pathway activation may play essential roles in the pathogenesis of dry AMD. There are no available drugs for dry AMD. Qihuang Granule (QHG) is an herbal formula for the treatment of dry AMD, and it achieves a good clinical effect in our hospital. However, its potential mechanism is unclear. Our study investigated the effects of QHG on oxidative stress-associated retinal damage to reveal its underlying mechanism.

Methods

Oxidative stress models were established using H₂O₂ and NaIO₃ in ARPE-19 cells and C57BL/6 mice. Cell apoptosis and viability were assess

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9938598 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature