Inhibition of alternative oxidase disrupts the development and oviposition of Biomphalaria glabrata snails.

ABSTRACT:

Background

Biomphalaria glabrata is one of the main intermediate hosts of Schistosoma mansoni, the most widespread species of Schistosoma. Our previous studies proved that alternative oxidase (AOX), the terminal oxidase in the mitochondrial respiratory chain, widely exists in several species of intermediate host snails of Schistosoma. Meanwhile, inhibition of AOX activity in Oncomelania hupensis snails could dramatically enhance the molluscicidal effect of niclosamide. As a hermaphroditic aquatic mollusc, the high fecundity and population density of B. glabrata increase the difficulty of snail control, which is one of the critical strategies for schistosomiasis elimination. The present study aimed to investigate the possible role of AOX in the development and fecundity of B. glabra

SUBMITTER: Xu S 

PROVIDER: S-EPMC9938623 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature