Characterizing the follicular fluid metabolome: quantifying the correlation across follicles and differences with the serum metabolome.

ABSTRACT:

Objective

To compare the variability in metabolomes between the serum and follicular fluid, as well as across 3 dominant follicles.

Design

Prospective cohort study.

Setting

An academic fertility clinic in the northeastern United States, 2005-2015.

Patients

One hundred thirty-five women undergoing in vitro fertilization treatment who provided a serum sample during ovarian stimulation and up to 3 follicular fluid samples during oocyte retrieval.

Intervention(s)

None.

Main outcome measure(s)

Samples were analyzed using liquid chromatography with high-resolution mass spectrometry and 2 chromatography columns (C18 hydrophobic negative and hydrophilic interaction chromatography [HILIC] positive). We calculated overall, feature-specific, and subject-spec

SUBMITTER: Hood RB 

PROVIDER: S-EPMC9938636 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature