Immune cell landscape in symptomatic and asymptomatic SARS-CoV-2 infected adults and children in urban Dhaka, Bangladesh.

ABSTRACT:

Objectives

The study of cellular immunity to SARS-CoV-2 is crucial for evaluating the course of the COVID-19 disease and for improving vaccine development. We aimed to assess the phenotypic landscape of circulating lymphocytes and mononuclear cells in adults and children who were seropositive to SARS-CoV-2 in the past 6 months.

Methods

Blood samples (n = 350) were collected in a cross-sectional study in Dhaka, Bangladesh (Oct 2020-Feb 2021). Plasma antibody responses to SARS-CoV-2 were determined by an electrochemiluminescence immunoassay while lymphocyte and monocyte responses were assessed using flow cytometry including dimensionality reduction and clustering algorithms.

Results

SARS-CoV-2 seropositivity was observed in 52% of adults (18-65 years) and 56% of childre

SUBMITTER: Akhtar E 

PROVIDER: S-EPMC9938758 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature